HCID 69320502, 화합물 → HCID 11313604, 화합물

HRID 2114610노트

반응식

HRID 2114610 반응식
[CH:1]1([N:6]2[C:10]3[N:11]=[CH:12][N:13]=[C:14]([NH2:15])[C:9]=3[C:8]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([N+:25]([O-])=O)[CH:23]=[CH:24][C:18]=4[N:17]=3)=[CH:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>[Pd].CN1C(=O)CCC1>[NH2:25][C:22]1[CH:23]=[CH:24][C:18]2[N:17]=[C:16]([C:8]3[C:9]4[C:14]([NH2:15])=[N:13][CH:12]=[N:11][C:10]=4[N:6]([CH:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)[CH:7]=3)[NH:20][C:19]=2[CH:21]=1

참가 물질

5

반응물 2

HCID 69320502HCID 69320502, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 11313604HCID 11313604, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

7-Cyclopentyl-5-(6-nitro-1H-benzoimidazol-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine (1E, 1.0 g) was combined with 10% Palladium on carbon (100 mg) in 50 mL of anhydrous NMP and subjected to 50 psi of hydrogen at room temperature for 24 hours. LCMS monitor suggested pure desired product (M/Z 333.5, retention time 0.70 min. with analytical HPLC method 4). The mixture was filtered through celite. Desired product was used as an NMP stock solution (concentration of about 0.92 g in 45 mL).

출처 및 근거

ORD 기록
ord-373af516af974060a6ac8d4d532569a7
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435739B2

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