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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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4-Fluorobenzylamine → n-(4-Fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-2-[1-(pyridin-2-ylcarbonyl)-1,2,3,4-tetrahydroquinolin-2-yl]-1,6-dihydropyrimidine-4-carboxamide

HRID 2114771
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인쇄 미리보기

반응식

HRID 2114771 반응식
C([O:9][C:10]1[C:15](=[O:16])[N:14]([CH3:17])[C:13]([CH:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]2[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[O:29])=[N:12][C:11]=1[C:36](OC)=[O:37])(=O)C1C=CC=CC=1.[F:40][C:41]1[CH:48]=[CH:47][C:44]([CH2:45][NH2:46])=[CH:43][CH:42]=1>CN(C=O)C>[F:40][C:41]1[CH:48]=[CH:47][C:44]([CH2:45][NH:46][C:36]([C:11]2[N:12]=[C:13]([CH:18]3[CH2:27][CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=4)[N:19]3[C:28]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)=[O:29])[N:14]([CH3:17])[C:15](=[O:16])[C:10]=2[OH:9])=[O:37])=[CH:43][CH:42]=1
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참가 물질

4

반응물 2

HCID 673264-FluorobenzylamineHCID 17961698Methyl 5-benzoyloxy-1-methyl-6-oxo-2-[1-(pyridin-2-ylcarbonyl)-1,2,3,4-tetrahydroquinolin-2-yl]-1,6-dihydropyrimidine-4-carboxylate

생성물 1

HCID 54708375n-(4-Fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-2-[1-(pyridin-2-ylcarbonyl)-1,2,3,4-tetrahydroquinolin-2-yl]-1,6-dihydropyrimidine-4-carboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

The residue of Step 2 was dissolved in DMF and 4-fluorobenzylamine (3 eq.) was added. The reaction mixture was stirred at 90° C. for 1 H. The title compound was purified by preparative HPLC and isolated as its trifluoroacetic salt (C18, gradient of CH3CN/H2O+0.01% TFA).

후처리

  1. customThe title compound was purified by preparative HPLC
  2. customisolated as its trifluoroacetic salt (C18, gradient of CH3CN/H2O+0.01% TFA)

출처 및 근거

ORD 기록
ord-82e81941485e4d5f83cc3c7db8111569
출처 데이터셋
uspto-grants-2008_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07435734B2

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