Nitric Acid → 7-Fluoro-1-methyl-5-nitro-1,3-dihydro-indol-2-one

HRID 2114865노트

반응식

HRID 2114865 반응식
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8](=[O:12])[CH2:7]2.[N+:13]([O-])([OH:15])=[O:14]>>[F:1][C:2]1[CH:3]=[C:4]([N+:13]([O-:15])=[O:14])[CH:5]=[C:6]2[C:10]=1[N:9]([CH3:11])[C:8](=[O:12])[CH2:7]2

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 119516747-Fluoro-1-methylindolin-2-one

생성물 1

HCID 119516757-Fluoro-1-methyl-5-nitro-1,3-dihydro-indol-2-one

실험 절차

7-Fluoro-1-methyl-1,3-dihydro-indol-2-one (7, 2.00 g, 0.0119 mol) is added portion wise to 70% nitric acid (10 ml) at −10° C. After the addition is complete, the reaction is allowed to warm to room temperature and then stirred for 20 hours. The mixture is diluted with ice water and the resulting precipitate filtered, washed with water, and dried under vacuum to give the title compound as a solid. HPLC r.t. 4.40 min.

후처리

  1. additionAfter the addition
  2. filtrationthe resulting precipitate filtered
  3. washwashed with water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-604b3d1dd6cc41a0b4d1970a95cd1b47
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435751B2

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