Nitric Acid → 7-Fluoro-1-(2-fluoro-ethyl)-5-nitro-1,3-dihydro-indol-2-one

HRID 2114886노트

반응식

HRID 2114886 반응식
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[CH2:7]2.[N+:15]([O-])([OH:17])=[O:16]>>[F:1][C:2]1[CH:3]=[C:4]([N+:15]([O-:17])=[O:16])[CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][F:13])[C:8](=[O:14])[CH2:7]2

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 739475797-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one

생성물 1

HCID 739475807-Fluoro-1-(2-fluoro-ethyl)-5-nitro-1,3-dihydro-indol-2-one

실험 절차

7-Fluoro-1-(2-fluoro-ethyl)-1,3-dihydro-indol-2-one (0.880 g, 0.0119 mol) is added portionwise to 70% nitric acid (8 ml) at −10° C. After the addition is complete, the reaction is allowed to warm to room temperature and then stirred for 24 hours. The mixture is diluted with ice water and the resulting precipitate filtered, washed with water, and dried under vacuum to give the title compound as a light brown solid. HPLC r.t. 4.65 min; MS for C10H8F2N2O3 m/z 243.3 (M+H)+.

후처리

  1. additionAfter the addition
  2. filtrationthe resulting precipitate filtered
  3. washwashed with water
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-8a5c39e54d3a42f1a067b722122fde5d
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435751B2

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