7-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one → 2-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-yl)-acetamide

HRID 2114978

반응식

HRID 2114978 반응식
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]2[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=2[CH:3]=1.[F:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][CH:19]2[CH2:24][CH2:23][N:22]([C:25](=[O:29])[C:26](O)=[O:27])[CH2:21][CH2:20]2)=[CH:16][CH:15]=1>C(OCC)C>[F:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][CH:19]2[CH2:20][CH2:21][N:22]([C:25](=[O:29])[C:26]([NH:1][C:2]3[CH:12]=[CH:11][C:5]4[NH:6][C:7](=[O:10])[CH2:8][O:9][C:4]=4[CH:3]=3)=[O:27])[CH2:23][CH2:24]2)=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 27641827-amino-3,4-dihydro-2H-1,4-benzoxazin-3-oneHCID 51342220[4-(4-Fluorobenzyl)piperidin-1-yl](oxo)acetic acid

생성물 1

HCID 691002942-[4-(4-Fluoro-benzyl)-piperidin-1-yl]-2-oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-yl)-acetamide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

The title compound is prepared from 7-amino-4H-benzo[1,4]oxazin-3-one [J. Med. Chem., 32, 1627. (1989)] and [4-(4-fluoro-benzyl)-piperidin-1-yl]-oxo-acetic acid (Example 1b) according to the method described in Example 2. Melting Point: 209-212° C. (diethylether)

출처 및 근거

ORD 기록
ord-a4539e1ee9294ca29e440a2667a4b117
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435744B2

연결된 노트

불러오는 중…