Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Amino-2-hydroxybenzimidazole → 2-Oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-6-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Amino-2-hydroxybenzimidazole | HCID 66765 | — |
| 반응물 | Oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid | HCID 69100252 | — |
| 생성물 | 2-Oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-6-yl)-2-(4-p-tolyloxy-piperidin-1-yl)-acetamide | HCID 10200650 | — |
반응 단계
The title compound is prepared from oxo-(4-p-tolyloxy-piperidin-1-yl)-acetic acid (Example 26b) and 5-amino-1,3-dihydro-benzimidazol-2-one according to the method described in Example 2. The filtered crystals are purified by column chromatography using Kieselgel 60 (Merck) as adsorbent and toluene:methanol=4:1 as eluent. Melting Point: 294° C. (isopropanol)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07435744B2 |
| 출처 데이터셋 | uspto-grants-2008_10 |
| ORD ID | ord-51dff2f588f14f02843a66f108ba7efb |
| 출처 메모 | uspto-grants-2008_10 |