4-(2-Phenylethyl)piperidine → 2-Oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-2-(4-phenethyl-piperidin-1-yl)-acetamide

HRID 2115013노트

반응식

HRID 2115013 반응식
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([NH:12][C:13](=[O:17])[C:14]([OH:16])=O)=[CH:11][C:5]=2[O:4][CH2:3]1.[CH2:18]([CH:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1)[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(OCC)C>[O:16]=[C:14]([N:29]1[CH2:30][CH2:31][CH:26]([CH2:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:27][CH2:28]1)[C:13]([NH:12][C:10]1[CH:9]=[CH:8][C:6]2[NH:7][C:2](=[O:1])[CH2:3][O:4][C:5]=2[CH:11]=1)=[O:17]

참가 물질

4

반응물 2

HCID 43418954-(2-Phenylethyl)piperidineHCID 69100554N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid

생성물 1

HCID 691002592-Oxo-N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-2-(4-phenethyl-piperidin-1-yl)-acetamide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

The title compound is prepared from N-(3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-7-yl)-oxalamic acid (Example 53b) and 4-phenethyl-piperidine [J. Amer. Chem. Soc., 72, 4953. (1950)] according to the method described in Example 1c. Melting Point: 128-132° C. (diethylether)

출처 및 근거

ORD 기록
ord-8da8834830fe49d3ac158fb98d2c50c2
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07435744B2

반응 노트

불러오는 중…