Cycloheptylamine → 1-Cycloheptyl-5-oxo-pyrrolidine-3-carboxylic acid methyl ester
반응식
[C:1]([O:10][CH3:11])(=[O:9])[C:2]([CH2:4][C:5](OC)=[O:6])=[CH2:3].[CH:12]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1>CO>[CH3:11][O:10][C:1]([CH:2]1[CH2:4][C:5](=[O:6])[N:19]([CH:12]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[CH2:3]1)=[O:9]참가 물질
4
실험 절차
A solution of dimethyl itaconate (0.5 g, 3.16 mmoles), cycloheptylamine (0.357 g, 3.16 mmoles) in methanol (5 mL) was heated at 85° C. for eighteen hours. The solvent was evaporated in vacuo and the resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80) to give the title compound as a colorless oil.
후처리
- customThe solvent was evaporated in vacuo
- customthe resulting crude product was purified by flash chromatography (hexanes/ethyl acetate 80:20 to 20:80)
출처 및 근거
- ORD 기록
- ord-e29734af3c984ed7a97bdc7181932f28
- 출처 데이터셋
- uspto-grants-2008_10
- 특허 번호
- US07435833B2
반응 노트
불러오는 중…