P-Anisidine → 2-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester

반응식

[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.CO[CH:12]=[C:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH:7][CH:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:5][CH:4]=1

참가 물질

반응물 2

HCID 7732P-Anisidine

HCID 3016162Diethyl methoxymethylenemalonate

생성물 1

HCID 6189812-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester

반응 조건

온도: 100 °C

실험 절차

In a flask maintained under reduce pressure, p-methoxyaniline (35.1 g, 280 mmol) and diethyl 2-(methoxymethylene)malonate (73.97 g, 340 mmol) were stirred at 100° C. for two h. The crude mixture was used without further purification.

후처리

temperatureIn a flask maintained
customThe crude mixture was used without further purification

출처 및 근거

ORD 기록: ord-a8581a332a2646138cd0e8458a2b60ba
출처 데이터셋: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07435823B2

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