HCID 23103640, 화합물 → 4-(4-Ethylbenzyl)-3-hydroxypyridine

HRID 2116484노트

반응식

HRID 2116484 반응식
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[OH:17])O)=[CH:5][CH:4]=1)[CH3:2]>[Pd].C(O)(=O)C>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][C:12]=2[OH:17])=[CH:5][CH:4]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 23103640HCID 23103640, 화합물

생성물 1

HCID 231036434-(4-Ethylbenzyl)-3-hydroxypyridine수율 40%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

Next, to a mixture of (4-ethylphenyl)-(3-hydroxypyridin-4-yl)-methanol (10.54 g, 46.0 mmol) and acetic acid (100 ml), 5% palladium/carbon (5.0 g) was added and stirred under a hydrogen atmosphere at room temperature for 7 hours. After filtration to remove the insoluble materials, the filtrate was concentrated under reduced pressure and the resulting residue was recrystallized (ethyl acetate) to give the titled compound (3.91 g, 40%) as a colorless powder. Moreover, the mother liquor was purified by NH silica gel column chromatography (chloroform:methanol=20:1) to give 4-(4-ethylbenzyl)-3-hydroxypyridine (4.55 g, 46%) as a light-brown powder.

후처리

  1. additionwas added
  2. filtrationAfter filtration
  3. customto remove the insoluble materials
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customthe resulting residue was recrystallized (ethyl acetate)

출처 및 근거

ORD 기록
ord-1bf123a11d6440c39ae6436454dcd890
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07439232B2

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