4-Chloro-2-methylthiopyrimidine → 4-Fluoro-2-(methylsulfanyl)pyrimidine
반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[F-:10].[K+]>COCCOCCOCCOCCOC.C1OCCOCCOCCOCCOCCOC1>[F:10][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1참가 물질
5
반응 조건
- 온도
- 150 °C
실험 절차
To a solution of 35.7 g (0.22 mol) of 4-chloro-2-methylthiopyrimidine (Aldrich Chemical Co., Milwaukee, Wis., USA) in 135 mL of tetraglyme was added 18-crown-6 (1.33 g) and potassium fluoride (Anhydrous, Aldrich Chemical Co., Milwaukee, Wis., USA, 80 g). The mixture was heated at 150° C. with stirring for 16 hours. The mixture was then cooled and distilled under reduced pressure to give 20 g (62%) of 4-fluoro-2-methylthiopyrimidine as a liquid.
후처리
- temperatureThe mixture was then cooled
- distillationdistilled under reduced pressure
출처 및 근거
- ORD 기록
- ord-ab09a893db624d60b2185d6770ccf7d4
- 출처 데이터셋
- uspto-grants-2008_10
- 특허 번호
- US07439247B2
반응 노트
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