Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Tolterodine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | (R)-2-(3-(Diisopropylamino)-1-phenylpropyl)-4-methylphenol 2,3-dihydroxysuccinate | HCID 9847786 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | Tolterodine | HCID 443879 | — |
반응 단계
Tolterodine tartrate (2.1 g) is mixed with water (45 ml) and toluene (2.5 ml). Sodium carbonate (800 mg) is added to the slurry. Sodium hydroxide (2.0 N, 1.5 ml) is added. The mixture is extracted three times with toluene (3 ml), saving the organic phase. Anhydrous potassium carbonate is added to the organic phase dissolve the tolterodine tartate, giving the title compound in solution.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07439397B2 |
| 출처 데이터셋 | uspto-grants-2008_10 |
| ORD ID | ord-00454ea3d27d4de6ae950ba71adb20fc |
| 출처 메모 | uspto-grants-2008_10 |