Potassium Carbonate → 4-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide

HRID 2117296

반응식

HRID 2117296 반응식
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=O.[N+]([O-])(O)=O.[C:19]([NH:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=1)(=[NH:21])[NH2:20].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[CH:4]=[CH:3][N:20]=[C:19]([NH:22][C:23]3[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=3)[N:21]=2)=[CH:8][CH:9]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 5375260(E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-oneHCID 178512511HCID 178512511, 화합물

생성물 1

HCID 100419644-((4-(4-Chlorophenyl)pyrimidin-2-yl)amino)benzamide

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (0.10 g, 0.48 mmol), 4-(amidinoamino)benzamide nitrate (0.116 g, 0.48 mmol), and potassium carbonate (0.132 g, 0.96 mmol) in ethanol (10 ml) with was heated to 120° C. overnight in a sealed vessel. The reaction mixture was cooled to room temperature and the resulting solid was collected then washed with ethanol, water, and diethyl ether to provide the title compound as a beige solid, identical in all respects with the compound prepared in Example 1.

후처리

  1. customthe resulting solid was collected
  2. washthen washed with ethanol, water, and diethyl ether

출처 및 근거

ORD 기록
ord-0198378fc3b04776accb57ee32bc73f7
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442699B2

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