2-Isopropoxy-5-methylsulfonylbenzoic acid → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[7-(morpholine-4-sulfonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

HRID 2117415

반응식

HRID 2117415 반응식
[N:1]1([S:7]([C:10]2[CH:19]=[C:18]3[C:13]([CH2:14][CH2:15][NH:16][CH2:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH:20]([O:23][C:24]1[CH:32]=[CH:31][C:30]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:29][C:25]=1[C:26](O)=[O:27])([CH3:22])[CH3:21]>>[CH:20]([O:23][C:24]1[CH:32]=[CH:31][C:30]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:29][C:25]=1[C:26]([N:16]1[CH2:15][CH2:14][C:13]2[C:18](=[CH:19][C:10]([S:7]([N:1]3[CH2:2][CH2:3][O:4][CH2:5][CH2:6]3)(=[O:9])=[O:8])=[CH:11][CH:12]=2)[CH2:17]1)=[O:27])([CH3:22])[CH3:21]

참가 물질

3

반응물 2

HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acidHCID 219836637-(Morpholine-4-sulfonyl)-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 58677896(2-Isopropoxy-5-methanesulfonyl-phenyl)-[7-(morpholine-4-sulfonyl)-3,4-dihydro-1H-isoquinolin-2-yl]-methanone

실험 절차

Prepared in analogy to example 1.1 from 7-(morpholine-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline (CA [185059-05-6]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1). MS (m/e): 523.2 (M+H+).

출처 및 근거

ORD 기록
ord-475930b4f64d4c9ab0b8355780a61fd0
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442710B2

연결된 노트

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