4-(Pyrimidin-2-yl)benzaldehyde → 3-{3-[(4-Pyrimidin-2-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

HRID 2117512

반응식

HRID 2117512 반응식
Cl.[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH2:14])[CH:8]=1.[N:16]1[CH:21]=[CH:20][CH:19]=[N:18][C:17]=1[C:22]1[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=1>CO>[CH3:2][O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([CH2:13][NH:14][CH2:26][C:25]2[CH:24]=[CH:23][C:22]([C:17]3[N:16]=[CH:21][CH:20]=[CH:19][N:18]=3)=[CH:29][CH:28]=2)[CH:8]=1

참가 물질

4

반응물 2

HCID 127037224-(Pyrimidin-2-yl)benzaldehydeHCID 22282736Methyl 3-(3-(aminomethyl)phenyl)propanoate hydrochloride

생성물 1

HCID 536352203-{3-[(4-Pyrimidin-2-yl-benzylamino)-methyl]-phenyl}-propionic acid methyl ester

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The title compound of Step A was prepared from 3-(3-aminomethyl-phenyl)-propionic acid methyl ester hydrochloride salt, of Preparation 44, and 4-pyrimidin-2-yl-benzaldehyde, of Preparation 21, using the method described in Example 1, Step A except that the imine was formed in MeOH at reflux with a reaction time of 2 h. 1H NMR (400 MHz, CDCl3) δ 8.79 (d, 2H), 8.40 (d, 2H), 7.49 (d, 2H), 3.88 (s, 2H), 3.80 (s, 2H), 3.65 (s, 3H), 2.94 (t, 2H), 2.63 (t, 2H).

후처리

  1. temperatureat reflux with a reaction time of 2 h

출처 및 근거

ORD 기록
ord-cc3ad4ca7898404fae94b3f247762051
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442702B2

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