4-(1-Methyl-2-(2-methylprop-1-enyl)imidazol-5-yl)-2-anilinopyrimidine → HCID 69314355, 화합물

HRID 2117759노트

반응식

HRID 2117759 반응식
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[N:8]=2)=[CH:5][N:4]=[C:3]1[CH:20]=[C:21]([CH3:23])[CH3:22]>C(O)C.[Pd]>[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([NH:13][C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)[N:8]=2)=[CH:5][N:4]=[C:3]1[CH2:20][CH:21]([CH3:23])[CH3:22]

참가 물질

4

반응물 1

HCID 693092264-(1-Methyl-2-(2-methylprop-1-enyl)imidazol-5-yl)-2-anilinopyrimidine

생성물 1

HCID 69314355HCID 69314355, 화합물수율 71%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

4-(1-Methyl-2-(2-methylprop-1-enyl)imidazol-5-yl)-2-anilinopyrimidine (method 110; 400 mg, 1.3 mmol), and 10% Pd on C catalyst (150 mg), in ethanol (50 ml), was hydrogenated at 40 C and 20 bar for 18 hours. The catalyst was removed by filtration and the filter pad washed with ethanol. The solvent was evaporated and the residue triturated with ether and collected by filtration to give the title compound (280 mg, 71%). M/z: 308.

후처리

  1. customThe catalyst was removed by filtration
  2. washthe filter pad washed with ethanol
  3. customThe solvent was evaporated
  4. customthe residue triturated with ether
  5. filtrationcollected by filtration

출처 및 근거

ORD 기록
ord-29c1ce49c6e043ca9c89de0e1ce2ea06
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442697B2

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