Dimethylformamide → HCID 21914877, 화합물

HRID 2117865노트

반응식

HRID 2117865 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]2[N:12]=[C:13]([NH:16][C:17](=[O:19])[CH3:18])[S:14][CH:15]=2)=[CH:5][CH:4]=1.[O:20]1[CH2:24]CCC1.C[N:26](C)[CH:27]=[O:28]>O>[CH:27]([N:26]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]2[N:12]=[C:13]([NH:16][C:17](=[O:19])[CH3:18])[S:14][CH:15]=2)=[CH:5][CH:4]=1)[CH:24]=[O:20])=[O:28]

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 21915305HCID 21915305, 화합물

생성물 1

HCID 21914877HCID 21914877, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a mixture of N-(4-{2-[4-(bromomethyl)phenyl]ethyl}-1,3-thiazol-2-yl)acetamide (100 mg), tetrahydrofuran (2 ml) and N,N-dimethylformamide (2 ml) was added sodium diformylimide (42 mg), and the mixture was stirred at ambient temperature for 1 hour. The reaction mixture was diluted with water (3 ml), and the precipitated solid was filtered and washed with water to give N-[4-(2-{4-[(diformylamino)-methyl]phenyl}ethyl)-1,3-thiazol-2-yl]acetamide (80 mg).

후처리

  1. filtrationthe precipitated solid was filtered
  2. washwashed with water

출처 및 근거

ORD 기록
ord-a09f73d2191d40f5b93e5a5322c5977e
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442715B2

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