Acetic Acid → HCID 21063991, 화합물

HRID 2118013노트

반응식

HRID 2118013 반응식
[Cl:1]Cl.[OH:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[NH:12][C:13](=[O:15])[CH3:14].[C:16]([OH:19])(=O)[CH3:17]>>[C:13]([NH:12][C:7]1[CH:8]=[CH:9][C:10]([Cl:1])=[CH:11][C:6]=1[CH2:5][CH2:4][O:3][C:16](=[O:19])[CH3:17])(=[O:15])[CH3:14]

참가 물질

4

반응물 3

HCID 176Acetic Acid2회HCID 24526ChlorineHCID 50350Acetanilide, 2'-(2-hydroxyethyl)-

생성물 1

HCID 21063991HCID 21063991, 화합물

실험 절차

A solution of chlorine in glacial acetic acid (0.98M, 30 ml) was added dropwise to a solution of N-[2-(2-Hydroxy-ethyl)-phenyl]-acetamide (5.0 g, 27.9 mmol)(see reference Biochemistry 1979, 18(5), 860) in glacial acetic acid (50 ml) and the mixture was stirred at room temperature for 20 hours. The glacial acetic acid was removed under reduced pressure. The resulting oil was triturated with diethyl ether to give the title compound (3.3 g) as a pale yellow solid after filtration.

후처리

  1. customThe glacial acetic acid was removed under reduced pressure
  2. customThe resulting oil was triturated with diethyl ether

출처 및 근거

ORD 기록
ord-39ef470c62b04361941c765c217e15ac
출처 데이터셋
uspto-grants-2008_10
특허 번호
US07442795B2

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