Boron tribromide → 2-{4-Fluoro-alpha-[(2-methylquinazolin-5-yl)amino]-2-methoxybenzyl}-1,1,1-trifluoro-4-methylpent-3-en-2-ol
반응식
B(Br)(Br)Br.[F:5][C:6]1[CH:34]=[CH:33][C:9]([CH:10]([C:23]([OH:32])([CH2:28][C:29]([CH3:31])=[CH2:30])[C:24]([F:27])([F:26])[F:25])[NH:11][C:12]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:13]=2[CH:14]=[N:15][C:16]([CH3:22])=[N:17]3)=[C:8]([O:35][CH3:36])[CH:7]=1>CCCCCC.C(OCC)(=O)C>[F:5][C:6]1[CH:34]=[CH:33][C:9]([CH:10]([C:23]([OH:32])([CH:28]=[C:29]([CH3:30])[CH3:31])[C:24]([F:26])([F:25])[F:27])[NH:11][C:12]2[CH:21]=[CH:20][CH:19]=[C:18]3[C:13]=2[CH:14]=[N:15][C:16]([CH3:22])=[N:17]3)=[C:8]([O:35][CH3:36])[CH:7]=1참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
Analogously to Example 6, 340 mg (1.1 mmol) of 4-(4-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-(trifluoromethyl)pentanal and 211 mg (1.32 mmol) of 5-amino-2-methylquinazoline (described in Example 6) are reacted with 0.46 ml (2.2 mmol) of titanium tetraethylate to form imine. After analogous rearrangement with boron tribromide and subsequent chromatography on silica gel with hexane-ethyl acetate (0-50%), 156 mg of a mixture that consists of 2-{4-fluoro-alpha-[(2-methylquinazolin-5-yl)amino]-2-methoxybenzyl}-1,1,1-trifluoro-4-methylpent-4-en-2-ol and 2-{4-fluoro-alpha-[(2-methylquinazolin-5-yl)amino]-2-methoxybenzyl}-1,1,1-trifluoro-4-methylpent-3-en-2-ol is obtained. The separation is carried out by means of preparative thin-layer chromatography on silica gel (dichloromethane/2-propanol 5%) and yields 51 mg of the main component and 9 mg of the minor component.