1H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)oxiranyl]methyl]- → 1-[2-(2,4-Dichlorophenyl)-2-hydroxy-3-(1-methylimidazol-2-ylthio)-propyl]-1,2,4-triazole

HRID 2118491노트

반응식

HRID 2118491 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)[CH2:11][O:10]1.[SH:18][C:19]1[N:20]([CH3:24])[CH:21]=[CH:22][N:23]=1>O1CCOCC1>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:10])([CH2:11][S:18][C:19]1[N:20]([CH3:24])[CH:21]=[CH:22][N:23]=1)[CH2:12][N:13]1[CH:17]=[N:16][CH:15]=[N:14]1

참가 물질

4

반응물 2

HCID 104232291H-1,2,4-Triazole, 1-[[2-(2,4-dichlorophenyl)oxiranyl]methyl]-HCID 178480602HCID 178480602, 화합물

생성물 1

HCID 201939451-[2-(2,4-Dichlorophenyl)-2-hydroxy-3-(1-methylimidazol-2-ylthio)-propyl]-1,2,4-triazole수율 66%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-yl-methyl)-oxirane (0.27 g, 0.001 m), and 2-mercapto-1-methylimidazole (0.228 g, 0.002 m) were heated under reflux in dioxan for 72 hours. The dioxan was then evaporated and the residue was dissolved in ethyl acetate (70 ml). This solution was washed sequentially with dilute potassium carbonate solution, dilute sodium hydroxide solution, and water dried (MgSO4) and evaporated to give an oil which crystallized on standing. Recrystallization from ethyl acetate/hexane gave the title compound 0.252 g (66%); m.p. 159°-161° C.

후처리

  1. customThe dioxan was then evaporated
  2. dissolutionthe residue was dissolved in ethyl acetate (70 ml)
  3. washThis solution was washed sequentially with dilute potassium carbonate solution, dilute sodium hydroxide solution, and water
  4. dry with materialdried (MgSO4)
  5. customevaporated
  6. customto give an oil which
  7. customcrystallized
  8. customRecrystallization from ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-90d982b6a7664c1e9b9f06b2340b6c9a
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04678789

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