Nitric Acid → 1H-Imidazole, 4-methyl-5-nitro-

HRID 2118542노트

반응식

HRID 2118542 반응식
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[N+:7]([O-])([OH:9])=[O:8].S(=O)(=O)(O)O>>[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[N+:7]([O-:9])=[O:8]

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178418800HCID 178418800, 화합물

생성물 1

HCID 862781031H-Imidazole, 4-methyl-5-nitro-수율 41.6%

반응 조건

온도
100 °C

실험 절차

4-Methylimidazole (10 g, 0.12 moles), was cooled in a flask, and fuming nitric acid (11 ml, 0.24 moles) was added dropwise. This was followed by the addition of sulfuric acid (11 ml). The reaction was then heated with stirring at 100° C. for 21/2 hours. The cooled reaction mixture was then added to 500 ml of ice water, and the precipitate was filtered off. The filtrate was neutralized with ammonium hydroxide, and filtered again. The combined precipitates were then recrystallized from water to give 6.35 g of 4-methyl-5-nitroimidazole.

후처리

  1. temperatureThe reaction was then heated
  2. customThe cooled reaction mixture
  3. filtrationthe precipitate was filtered off
  4. filtrationfiltered again
  5. customThe combined precipitates
  6. customwere then recrystallized from water

출처 및 근거

ORD 기록
ord-1047adf5abe64db5a19761ff3104dd6d
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04678799

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