Pyridine → N-(3-Formamido-2-oxoazetidin-3-yl)-2-phenoxyacetamide
반응식
[NH2:1][C:2]1([NH:7][C:8](=[O:17])[CH2:9][O:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:5][NH:4][C:3]1=[O:6].N1C=CC=CC=1.[C:24](OC=O)(=[O:26])C>ClCCl>[CH:24]([NH:1][C:2]1([NH:7][C:8](=[O:17])[CH2:9][O:10][C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:5][NH:4][C:3]1=[O:6])=[O:26]참가 물질
5
실험 절차
The amine (27) (66 mg) in dry dichloromethane (5 ml) was cooled to 0° and treated with pyridine (49 mg) followed by formic-acetic anhydride (27 mg). The mixture was stirred at 0° for 15 minutes then allowed to warm to room temperature over 15 minutes, and evaporated to dryness. The residue was chromatographed on silica gel to give the product (28) (53 mg).
후처리
- customevaporated to dryness
- customThe residue was chromatographed on silica gel
출처 및 근거
- ORD 기록
- ord-4432247a9a624c7b939ff6668434f4c0
- 출처 데이터셋
- uspto-grants-1987_07
- 특허 번호
- US04678782
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