Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tributylvinyltin → 7-Amino-4-vinylisoindolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tributylvinyltin | HCID 81998 | — |
| 반응물 | 7-Amino-4-bromo-2,3-dihydroisoindol-1-one | HCID 19701932 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 7-Amino-4-vinylisoindolinone | HCID 68488659 | 68% |
반응 단계
In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (300 mg, 1.32 mmol) was dissolved in THF (12 mL), and the solution was treated with vinyltributyltin (1.16 mL, 3.96 mmol) and bis(o-toluoylphosphine)dichloropalladium (166 mg, 0.211 mmol), followed by purification by slurry using hexane and chloroform to obtain 7-amino-4-vinylisoindolinone (155 mg, yield 68%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-dd23c3d5e843441b888f71abd7d17ffd |
| 출처 메모 | uspto-grants-2010_06 |