Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-Bromo-5-nitroisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Nitrate | HCID 24434 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1-Bromoisoquinoline | HCID 640963 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Bromo-5-nitroisoquinoline | HCID 14617005 | — |
반응 단계
The starting material was prepared by reaction of 1-bromoisoquinoline in concentrated H2SO4 at 0° with KNO3. The reaction mixture was worked up with water, NaHCO3 and EtOAc to give 1-bromo-5-nitro isoquinoline, m.p. 187°-8°. Reaction of this compound with trimethyloxonium tetrafluoroborate in CH2Cl2 gave impure 1-bromo-2-methyl-5-nitroisoquinolinium tetrafluoroborate which was used as such. n.m.r in solvent A: 3.5(s, 3H); 7.7-8.7(m, 5H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04678781 |
| 출처 데이터셋 | uspto-grants-1987_07 |
| ORD ID | ord-bfe9906dc12d4c22afc26da89b0bab9b |
| 출처 메모 | uspto-grants-1987_07 |