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Water → 2-[(6-Chlorohexyl)oxy]-1,1′-biphenyl

HRID 2118662
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HRID 2118662 반응식
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]OS(C1C=CC(C)=CC=1)(=O)=O.[OH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[C:21]1([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:20]([O:19][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][Cl:1])=[CH:25][CH:24]=[CH:23][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 7017(1,1'-Biphenyl)-2-olHCID 11430Potassium CarbonateHCID 561724HCID 561724, 화합물

생성물 1

HCID 201928952-[(6-Chlorohexyl)oxy]-1,1′-biphenyl

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1-Chloro-6-(p-toluenesulphonyloxy)hexane (100 g), 2-hydroxybiphenyl (59 g) and potassium carbonate (60 g) were heated with stirring in dimethylformamide at 70° for 16 hours. The solution was cooled and added to water, then extracted with ether. The extract was washed with water, dried and evaporated, and the residue was chromatographed on silica gel (1800 g) eluting with 99:1 hexane; ethyl acetate, so as to afford the title compound as an oil.

후처리

  1. temperatureThe solution was cooled
  2. extractionextracted with ether
  3. washThe extract was washed with water
  4. customdried
  5. customevaporated
  6. customthe residue was chromatographed on silica gel (1800 g)
  7. washeluting with 99:1 hexane

출처 및 근거

ORD 기록
ord-4d15e15712ac4425a3cf055e8cfe13fe
출처 데이터셋
uspto-grants-1987_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04680300

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