Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Piperazinecarboxylic acid, ethyl ester → 2-Tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Piperazinecarboxylic acid, ethyl ester | HCID 8431 | — |
| 반응물 | 2-Tert-butyl-5-chloro-6-nitrobenzothiazole | HCID 19794202 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole | HCID 20192932 | — |
반응 단계
A mixture of 3.5 g of 2-tert.-butyl-5-chloro-6-nitrobenzothiazole, described in Example 5, and 5.8 g of N-carbethoxypiperazine is heated at 180° for 2 hours, cooled and poured into water. The solid is filtered, washed with water and crystallised from isopropyl alcohol to give 2-tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole, melting at 100°-102°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04680301 |
| 출처 데이터셋 | uspto-grants-1987_07 |
| ORD ID | ord-bfa4d8d9fa174f29b8406fa1c70674a3 |
| 출처 메모 | uspto-grants-1987_07 |