Cyclopropylamine → HCID 67944888, 화합물

HRID 2118799노트

반응식

HRID 2118799 반응식
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.[Cl:5][C:6]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:7]=1[C:8]([C:10](=[CH:13]OC)[C:11]#[N:12])=[O:9]>C(O)C>[Cl:5][C:6]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:7]=1[C:8]([C:10](=[CH:13][NH:4][CH:1]1[CH2:3][CH2:2]1)[C:11]#[N:12])=[O:9]

참가 물질

4

반응물 2

HCID 69828CyclopropylamineHCID 537392442-(2,4-Dichloro-benzoyl)-3-methoxyacrylonitrile

생성물 1

HCID 67944888HCID 67944888, 화합물수율 86.9%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

2.5 g of cyclopropylamine are added dropwise to a solution of 11 g of 2-(2,4-dichloro-benzoyl)-3-methoxyacrylonitrile in 40 ml of ethanol, while cooling with ice and stirring. The mixture is stirred at room temperature for 25 minutes and then heated at the boiling point for 15 minutes. The solvent is removed in vacuo and the residue is recrystallized from ethanol/light petrol. 10.5 g of 2-(2,4-dichloro-benzoyl)-3-cyclopropylaminoacrylonitrile of melting point 93°-94° C. are obtained.

후처리

  1. temperaturewhile cooling with ice
  2. stirringThe mixture is stirred at room temperature for 25 minutes
  3. temperatureheated at the boiling point for 15 minutes
  4. customThe solvent is removed in vacuo
  5. customthe residue is recrystallized from ethanol/light petrol

출처 및 근거

ORD 기록
ord-0bbe747a015f421e9260b2046be396e5
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04680401

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