Piperidine → [2-(1-Piperidinyl)-3-nitrophenyl]-(4-chlorophenyl)-methanone

HRID 2118809

반응식

HRID 2118809 반응식
Cl[C:2]1[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=1)=[O:5].[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.C(=O)([O-])[O-].[Ca+2]>C(O)C>[N:20]1([C:13]2[C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=[CH:2][C:3]=2[C:4]([C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][CH:7]=2)=[O:5])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 10112Calcium CarbonateHCID 875720(2-Chloro-5-nitro-phenyl)-(4-chloro-phenyl)-methanone

생성물 1

HCID 20193523[2-(1-Piperidinyl)-3-nitrophenyl]-(4-chlorophenyl)-methanone수율 97%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Proceeding as in example 2, with 0.035 mole (10.4 g) of 2,4'-dichloro-5-nitro-benzophenone and 0.07 mole (6 g) of piperidine and 0.035 mole (5 g) of calcium carbonate mixed in ethanol, 11 g (Yield: 97%) of the expected product are obtained after recrystallization in ethanol. M.P.=141° C.

출처 및 근거

ORD 기록
ord-7d7d8dbd960c416c972f83faf07a8d90
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04680402

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