참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Bromo-methoxy-chroman | HCID 20193557 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Diisopropyl Ether | HCID 7914 | — |
| 생성물 | 8-Methoxychromane-6-carbaldehyde | HCID 12831983 | 51% |
반응 단계
The procedure is as according to the method described for preparation III, but maintaining the temperature at -50° C. From 186 g (7.7×10-1M) of bromo-methoxy-chroman Ib2 in 500 cm3 of anhydrous ether and 7.7×10-1M of n-butyllithium in 650 cm3 of anhydrous ether, and after addition of 78 g (1.1M) of N,N-dimethylformamide in 200 cm3 of anhydrous ether and recrystallisation in isopropyl ether, 75 g (yield=51%) of expected compound are isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04680411 |
|---|
| 출처 데이터셋 | uspto-grants-1987_07 |
|---|
| ORD ID | ord-7bd04b9411524ac1a93fde216abe0d4a |
|---|
| 출처 메모 | uspto-grants-1987_07 |
|---|
