2,3-Dihydro-1H-indole-7-sulfonamide → 1H-Indole-7-sulfonamide

HRID 2119115노트

반응식

HRID 2119115 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[S:10]([NH2:13])(=[O:12])=[O:11])[CH2:3][CH2:2]1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[S:10]([NH2:13])(=[O:11])=[O:12])[CH:3]=[CH:2]1

참가 물질

4

반응물 1

HCID 143467542,3-Dihydro-1H-indole-7-sulfonamide

생성물 1

HCID 143467551H-Indole-7-sulfonamide

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

반응 조건

온도
25 °C

실험 절차

To a slurry of activated manganese dioxide (20 g) in methylene chloride (200 ml) was added indoline-7-sulfonamide (4.3 g). The mixture was stirred at 25° C. for 24 hours. The solid was removed by filtration and the filtrate concentrated and hexane added until crystallization occurred. The pure product (TLC) was isolated by filtration (2.9 g, m.p. 125°-127° C.

후처리

  1. customThe solid was removed by filtration
  2. concentrationthe filtrate concentrated
  3. additionhexane added until crystallization
  4. customThe pure product (TLC) was isolated by filtration (2.9 g, m.p. 125°-127° C.

출처 및 근거

ORD 기록
ord-97079f0cbe764a9fb79556c108c8b21d
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04683000

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