1-Methylimidazole → HCID 70387076, 화합물

HRID 2119222노트

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HRID 2119222 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=1[CH3:12])=[O:4].[CH3:13][N:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>C(OCC)C>[Br-:1].[CH3:13][NH+:14]1[CH:18]=[CH:17][N:16]([CH2:2][C:3]([C:5]2[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:6]=2[CH3:12])=[O:4])[CH2:15]1

참가 물질

4

반응물 2

HCID 13901-MethylimidazoleHCID 20634502-Bromo-1-(2,4-dimethylphenyl)ethanone

생성물 1

HCID 70387076HCID 70387076, 화합물수율 51%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 4.76 g (0.021 mol) of 1-bromo-2-(2,4-dimethylphenyl)-2-oxoethane and 1.76 g (0.021 mol) of 1-methylimidazole in 50 ml of diethyl ether was stirred at room temperature for approximately 21 hours. The reaction solvent was decanted and the residue was washed with diethyl ether. The residue was recrystallized from acetonitrile/ethyl acetate to afford 3.32 g of the title product as white crystals. (51% yield) mp=179°-181° C.

후처리

  1. customThe reaction solvent was decanted
  2. washthe residue was washed with diethyl ether
  3. customThe residue was recrystallized from acetonitrile/ethyl acetate

출처 및 근거

ORD 기록
ord-de65f7ca93cf426faa8057562c722a00
출처 데이터셋
uspto-grants-1987_07
특허 번호
US04683312

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