Ethanol → HCID 15839201, 화합물

HRID 2119428노트

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HRID 2119428 반응식
[OH:1][CH:2]([C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3](N)=[O:4].[CH2:20]([OH:22])[CH3:21]>O>[OH:1][CH:2]([C:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[CH3:7])[C:3]([O:22][CH2:20][CH3:21])=[O:4]

참가 물질

4

반응물 2

HCID 702EthanolHCID 15839202HCID 15839202, 화합물

생성물 1

HCID 15839201HCID 15839201, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2.15 g (8.4 mmol) of 2-hydroxy-3,3-diphenylbutyramide were dissolved in 15 ml of ethanol, 15 ml of conc. HCI were added and the mixture was refluxed for 40 hours. The solvent was stripped off under reduced pressure, and the residue was taken up in water. The aqueous phase was extracted three times with ethyl acetate, and the combined organic phases were washed twice with 10% strength sodium hydroxide solution. Drying with MgSO4 and stripping off the solvent under reduced pressure resulted in 1.75 g (73%) of ethyl 2-hydroxy-3,3-diphenylbutyrate.

후처리

  1. addition15 ml of conc. HCI were added
  2. temperaturethe mixture was refluxed for 40 hours
  3. extractionThe aqueous phase was extracted three times with ethyl acetate
  4. washthe combined organic phases were washed twice with 10% strength sodium hydroxide solution
  5. dry with materialDrying with MgSO4
  6. customresulted in 1.75 g (73%) of ethyl 2-hydroxy-3,3-diphenylbutyrate

출처 및 근거

ORD 기록
ord-814c512e81664f438b7093d9be2d38d5
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686369B1

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