홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Triethylamine → 1-(2-Methoxy-phenyl)-3-{3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-urea

HRID 2119593
노트
인쇄 미리보기

반응식

HRID 2119593 반응식
Cl.[NH2:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]1[S:8][C:9]([C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[O:13])=[CH:10][N:11]=1.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]=[C:30]=[O:31].CCN(CC)CC>CO>[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[NH:29][C:30]([NH:2][CH2:3][CH2:4][CH2:5][NH:6][C:7]1[S:8][C:9]([C:12](=[O:13])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[CH3:20])=[CH:10][N:11]=1)=[O:31]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 69695Benzene, 1-isocyanato-2-methoxy-HCID 23442547[2-(3-Amino-propylamino)-thiazol-5-yl]-o-tolyl-methanone hydrochloride

생성물 1

HCID 234426401-(2-Methoxy-phenyl)-3-{3-[5-(2-methyl-benzoyl)-thiazol-2-ylamino]-propyl}-urea수율 47%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 12.5 mg (0.04 mmol) [2-(3-Amino-propylamino)-thiazol-5-yl]-o-tolyl-methanone hydrochloride, 7.6 mg (0.05 mmol) 2-Methoxyphenyl isocyanate and 39 ul NEt3 in 1 ml methanol was stirred for 16 h at room temperature. After evaporation to dryness the residue was taken up in 1.5 ml MeOH/formic acid 1/1 and subjected to preparative HPLC separation on reversed phase eluting with an acetonitrile/water gradient. Evaporation of product fractions yielded 7.9 mg (47%) of the title compound.

후처리

  1. customAfter evaporation to dryness the residue
  2. customHPLC separation on reversed phase
  3. washeluting with an acetonitrile/water gradient
  4. customEvaporation of product fractions

출처 및 근거

ORD 기록
ord-8a2a5b047cd84f01910febc32216e45c
출처 데이터셋
uspto-grants-2004_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06686381B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트