HCID 12985698, 화합물 → HCID 23442493, 화합물

반응식

[Cl:1][C:2]1[C:11]2[C:10](C(C)C)=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH:15]=[N:16][N:17]([CH3:18])[C:3]=12.[CH:19](C1C2C(=O)C3N(C)N=CC=3NC=2C=CC=1)([CH3:21])[CH3:20].ClC1C2C=CC(F)=CC=2N=C2C=NN(C)C=12.C(C1C=CC2C(=O)C3N(C)N=CC=3NC=2C=1)(C)C>>[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][C:8]([CH:19]([CH3:21])[CH3:20])=[CH:7][C:6]=2[N:5]=[C:4]2[CH:15]=[N:16][N:17]([CH3:18])[C:3]=12

참가 물질

반응물 4

HCID 12985698HCID 12985698, 화합물

HCID 23442346HCID 23442346, 화합물

HCID 23442370HCID 23442370, 화합물

HCID 23442408HCID 23442408, 화합물

생성물 1

HCID 23442493HCID 23442493, 화합물

실험 절차

A mixture of 9-chloro-8-isopropyl-1-methyl-1H-pyrazolo[4,3-b]quinoline and 9-chloro-6-isopropyl-1-methyl-1H-pyrazolo[4,3-b]quinoline (EXAMPLE 10, step 2) was treated according to the procedure of step 3 in EXAMPLE 3 instead of 9-chloro-6-fluoro-1-methyl-1H-pyrazolo[4,3-b]quinoline. The title compound and 6-isopropyl-1-methyl-1,4-dihydro-9H-pyrazolo[4,3-b]quinolin-9-one were separable by column chromatography on silica gel eluting with methanol/dichloromethane (1:30).