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Potassium Cyanide → HCID 23443402, 화합물

HRID 2119788
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HRID 2119788 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9](Cl)[CH:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[N:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[C-:23]#[N:24].[K+].C1(C)C=CC=CC=1S([O-])=O.[Na+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([C:23]#[N:24])[CH:10]([C:14]3[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=3[F:21])[N:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 9032Potassium CyanideHCID 23443407HCID 23443407, 화합물HCID 23676349Sodium 2-methylbenzene-1-sulfinate

생성물 1

HCID 23443402HCID 23443402, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

6 g of 4-(4-bromophenyl)-2-(2,6-difluorophenyl)-3-chloropyrimidine, 80 ml of dimethylformamide, 1.53 g of KCN and 0.93 g of sodium tolylsulfinate are mixed together, stirred for 3 hours at 80° C., mixed with ice water and filtered. After dissolving the precipitate in ethyl acetate, drying with magnesium sulfate, filtering and concentrating, the title compound is obtained with a melting point 146-148° C. (compound 3.355).

후처리

  1. filtrationfiltered
  2. dissolutionAfter dissolving the precipitate in ethyl acetate
  3. dry with materialdrying with magnesium sulfate
  4. filtrationfiltering
  5. concentrationconcentrating

출처 및 근거

ORD 기록
ord-d837c67e78654e75abc18bae4b2601f9
출처 데이터셋
uspto-grants-2004_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06686469B2

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