5-Chloro-2-methylphenyl isothiocyanate → 1-(5-Chloro-2-methyl-phenyl)-3-(1,3,5-trimethyl-1H-pyrazol-4-yl)-thiourea

HRID 2119796

반응식

HRID 2119796 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[NH2:12][C:13]1[C:14]([CH3:20])=[N:15][N:16]([CH3:19])[C:17]=1[CH3:18]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([NH:8][C:9]([NH:12][C:13]2[C:14]([CH3:20])=[N:15][N:16]([CH3:19])[C:17]=2[CH3:18])=[S:10])[CH:7]=1

참가 물질

3

반응물 2

HCID 295195-Chloro-2-methylphenyl isothiocyanateHCID 1616031,3,5-trimethyl-1H-pyrazol-4-amine

생성물 1

HCID 98578071-(5-Chloro-2-methyl-phenyl)-3-(1,3,5-trimethyl-1H-pyrazol-4-yl)-thiourea수율 71.4%

실험 절차

Prepared using Method A from 4.5 g (24.5 mmol) of 5-chloro-2-methyl-phenyl isothiocyanate and 3.06 g (24.5 mmol) of 4-amino-1,3,5-trimethylpyrazole to give 5.4 g of title compound as a white solid, m.p. 176-177° C. (71% yield).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-51a3b3caea164dab8a1511dae44885eb
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686476B2

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