Acetamidine monohydrochloride → 10-Fluoro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119952노트

반응식

HRID 2119952 반응식
CN([CH:4]=[C:5]1[C:11](=O)[C:10]2[CH:13]=[C:14]([F:17])[CH:15]=[CH:16][C:9]=2[NH:8][C:7](=[O:18])[CH2:6]1)C.Cl.[C:20]([NH2:23])(=[NH:22])[CH3:21]>>[F:17][C:14]1[CH:15]=[CH:16][C:9]2[NH:8][C:7](=[O:18])[CH2:6][C:5]3[CH:4]=[N:22][C:20]([CH3:21])=[N:23][C:11]=3[C:10]=2[CH:13]=1

참가 물질

3

반응물 2

HCID 67170Acetamidine monohydrochlorideHCID 669346104-Dimethylaminomethylene-7-fluoro-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

생성물 1

HCID 2344100610-Fluoro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-one수율 50%

실험 절차

Analogous to Scheme 1, from 4-[(dimethylamino)methylene]-7-fluoro-3,4-dihydro-1H-benzazepine-2,5-dione and acetamidine hydrochloride. Yield: 50%.

출처 및 근거

ORD 기록
ord-95487d93e84f4a20976fb34b46cf20ec
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686352B2

반응 노트

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