Acetamidine monohydrochloride → 10-Chloro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-one

HRID 2119960노트

반응식

HRID 2119960 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8](=[CH:13]N(C)C)[C:7](=O)[C:6]=2[CH:18]=1.Cl.[C:20]([NH2:23])(=[NH:22])[CH3:21]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[CH2:9][C:8]3[CH:13]=[N:22][C:20]([CH3:21])=[N:23][C:7]=3[C:6]=2[CH:18]=1

참가 물질

3

반응물 2

HCID 67170Acetamidine monohydrochlorideHCID 669347277-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione

생성물 1

HCID 1313357110-Chloro-5,7-dihydro-2-methyl-6h-pyrimido[5,4-d][1]benzazepin-6-one수율 58%

실험 절차

Analogous to Scheme 1, from 7-chloro-4-[(dimethylamino)methylene]-3,4-dihydro-1H-benzazepine-2,5-dione and acetamidine hydrochloride. Yield: 58%.

출처 및 근거

ORD 기록
ord-f06dbe43f18642d190752fb178805d1c
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686352B2

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