Water → 3-(Azidomethyl)-5-methyl-1,2-oxazole

HRID 2119980노트

반응식

HRID 2119980 반응식
Br[CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1.[N-:9]=[N+:10]=[N-:11].[Na+].O>CC(C)=O>[N:9]([CH2:2][C:3]1[CH:7]=[C:6]([CH3:8])[O:5][N:4]=1)=[N+:10]=[N-:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 33557Sodium AzideHCID 27763043-(Bromomethyl)-5-methylisoxazole

생성물 1

HCID 234409373-(Azidomethyl)-5-methyl-1,2-oxazole수율 242.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of the 3-bromomethyl-5-methyl-isoxazole (150 mg, 0.9 mmol) in acetone (1 mL) was added NaN3 (166 mg, 0.26 mmol) at rt. The reaction mixture was then stirred for 48 h. Then, the reaction mixture was poured into water (10 mL) and extracted with EtOAc (3×10 mL) dried and evaporated. The product was chromatographed on silica gel eluting with EtOAc/hexane 1:1 to leave the title compound as a colorless liquid (87 mg, 74%). m/z 138.0 (M).

후처리

  1. extractionextracted with EtOAc (3×10 mL)
  2. customdried
  3. customevaporated
  4. customThe product was chromatographed on silica gel eluting with EtOAc/hexane 1:1

출처 및 근거

ORD 기록
ord-0654f9e3377149beb4037a60a18fa66d
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06686352B2

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