Ethyl bromoacetate → Ethyl 2-(tetramethylcyclopentadienyl)acetate
반응식
Br[CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:8][C:9]1[CH-:13][C:12]([CH3:14])=[C:11]([CH3:15])[C:10]=1[CH3:16].[Na+]>C1COCC1>[CH3:8][C:9]1[CH:13]([CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4])[C:12]([CH3:14])=[C:11]([CH3:15])[C:10]=1[CH3:16]참가 물질
4
실험 절차
A solution of 3.822 g (22.89 mmol) ethyl bromoacetate in 25 mL THF was cooled to −78° C. and 3.000 g (20.80 g) sodium tetramethylcyclopentadienide in 50 mL THF was slowly added to it. The resulting slurry was allowed to warm to room temperature and was stirred overnight. The solvent was removed, the residue was extracted with pentane and filtered. The pentane was removed to give a mixture of isomers. Yield was 3.733 g (86.3%). Mass spectra m/e 208 (41 percent).
후처리
- customThe solvent was removed
- extractionthe residue was extracted with pentane
- filtrationfiltered
- customThe pentane was removed
- customto give
- additiona mixture of isomers
출처 및 근거
- ORD 기록
- ord-36be9dc8732d4c6ab705896d1722a614
- 출처 데이터셋
- uspto-grants-2004_02
- 특허 번호
- US06686488B2
반응 노트
불러오는 중…