Water → 2-(Benzenesulfonyl)acetamide

HRID 2120280노트

반응식

HRID 2120280 반응식
Br[CH2:2][C:3]([NH2:5])=[O:4].[C:6]1([S:12]([O:14][Na])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.O>CN(C=O)C>[C:6]1([S:12]([CH2:2][C:3]([NH2:5])=[O:4])(=[O:14])=[O:13])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 696322-BromoacetamideHCID 178527445HCID 178527445, 화합물

생성물 1

HCID 18103052-(Benzenesulfonyl)acetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of α-bromoacetamide IV in anhydrous DMF, is added PhSO2Na at 0° C. The reaction mixture is stirred for 1 hour at room temperature and is then poured into water. The organic layer is washed with brine, dried over Na2SO4, and evaporated. The residue is purified by silica gel column chromatography to give α-phenylsulfonylacetamide III.

후처리

  1. washThe organic layer is washed with brine
  2. dry with materialdried over Na2SO4
  3. customevaporated
  4. customThe residue is purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-65266f6a96dc47279dedb4650eca1c6a
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06689890B2

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