Morpholine → 5-(Morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester

반응식

[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][N:6]=1)([O:3][CH3:4])=[O:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N:14]1([C:9]([C:8]2[CH:12]=[CH:13][C:5]([C:1]([O:3][CH3:4])=[O:2])=[N:6][CH:7]=2)=[O:10])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 151211775-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester

생성물 1

HCID 206223075-(Morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester

실험 절차

In step b, the acid chloride (7) is amidated with morpholine (8) by techniques and procedures well known and appreciated by one of ordinary skill in the art to give the corresponding 5-(morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester (9).

출처 및 근거

ORD 기록: ord-f44e8e9f9e5e43bf88dc94f8c6462df3
출처 데이터셋: uspto-grants-2004_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06693072B2

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