2-Benzylideneamino-4-methylphenol → 2-Phenyl-5-methylbenzoxazole

HRID 2120605

반응식

HRID 2120605 반응식
[CH:1](=[N:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:10]=1[OH:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1(C)C=CC=CC=1.O.O.C([O-])(=O)C.[Mn+3].C([O-])(=O)C.C([O-])(=O)C>[CH3:15][C:13]1[CH:12]=[CH:11][C:10]2[O:16][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:8][C:9]=2[CH:14]=1

참가 물질

4

반응물 1

HCID 112987892-Benzylideneamino-4-methylphenol

생성물 1

HCID 819192-Phenyl-5-methylbenzoxazole수율 93.3%

시약·촉매·용매 2

HCID 12416832Manganese triacetate dihydrate촉매HCID 1140Toluene용매

실험 절차

A mixture of 2-benzylideneamino-4-methylphenol 54 (1.34 g, 6.3 mmol) and manganese (III) acetate dihydrate (3.4 g, 12.7 mmol) in toluene (65 ml) was heated at reflux under an atmosphere of N2 for 1 hr and cooled to room temperature. The mixture was filtered to remove the insoluble manganese salts. The filtrate was evaporated under reduced pressure. The residue was taken up in methylene chloride and purified by filtration to yield 1.23 g 5-methyl-2-phenylbenzoxazole 55.

후처리

  1. temperaturewas heated
  2. temperatureat reflux under an atmosphere of N2 for 1 hr
  3. filtrationThe mixture was filtered
  4. customto remove the insoluble manganese salts
  5. customThe filtrate was evaporated under reduced pressure
  6. filtrationpurified by filtration

출처 및 근거

ORD 기록
ord-05351556deb44d278080e5c583d27237
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06693098B2

연결된 노트

불러오는 중…