Malonic Acid → HCID 54424786, 화합물

HRID 2121089

반응식

HRID 2121089 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[C:6]([F:12])[CH:5]=1)([O-:3])=[O:2].C(O)(=O)[CH2:14][C:15]([OH:17])=[O:16]>C(O)C>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[CH:14][C:15]([OH:17])=[O:16])=[C:6]([F:12])[CH:5]=1)([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 867Malonic AcidHCID 45629192-Fluoro-4-nitrobenzaldehyde

생성물 1

HCID 54424786HCID 54424786, 화합물수율 90%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A suspension of 4-nitro-2-fluorobenzaldehyde (3.16 g, 18.7 mmol), malonic acid (2.14 g, 21 mmol) pyridine (catalytic) and ethanol (10 mL) was heated to reflux for 6 hours. The suspension became a clear solution upon heating. Upon cooling to room temperature solids formed and were isolated by filtration. The solids were washed with cool (15° C.) ethanol and then with 1N HCl and dried, giving 3.32 g 4-nitro-2-fluorocinnamic acid (90% yield).

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 6 hours
  3. temperatureupon heating
  4. customformed
  5. customwere isolated by filtration
  6. washThe solids were washed
  7. temperaturewith cool (15° C.) ethanol
  8. dry with materialwith 1N HCl and dried

출처 및 근거

ORD 기록
ord-e79f8de3f0804c18962f154ca5e0a4c4
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06693208B2

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