Ethyl 2-[4-(2-benzyloxyethyl)phenoxy]-2-methylpropionate → Ethyl 2-[4-(2-hydroxy-ethyl)-phenoxy]-2-methyl-propionate

HRID 2121845노트

반응식

HRID 2121845 반응식
C([O:8][CH2:9][CH2:10][C:11]1[CH:25]=[CH:24][C:14]([O:15][C:16]([CH3:23])([CH3:22])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:13][CH:12]=1)C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([O:15][C:16]([CH3:22])([CH3:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:24][CH:25]=1

참가 물질

4

반응물 1

HCID 15453494Ethyl 2-[4-(2-benzyloxyethyl)phenoxy]-2-methylpropionate

생성물 1

HCID 15229879Ethyl 2-[4-(2-hydroxy-ethyl)-phenoxy]-2-methyl-propionate수율 87.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of ethyl 2-[4-(2-benzyloxyethyl)phenoxy]-2-methylpropionate (480 mg) in ethanol (3.0 ml) was added 10% palladium on activated carbon (30 mg), and the mixture was stirred for 48 hours at room temperature under a hydrogen atmosphere. The catalyst was filtered off, and the solvent of the filtrate was removed under reduced pressure. Purification of the residue by medium pressure liquid column chromatography on silica gel (eluent:hexane/diethyl ether=1/1) gave ethyl 2-[4-(2-hydroxyethyl)phenoxy]-2-methylpropionate (310 mg).

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe solvent of the filtrate was removed under reduced pressure
  3. customPurification of the residue by medium pressure liquid column chromatography on silica gel (eluent:hexane/diethyl ether=1/1)

출처 및 근거

ORD 기록
ord-99d99ac2bd1e4ab6b09a18edc5e1833e
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06696489B1

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