Ethyl isocyanate → Acetic Acid 7-allyl-1-ethylcarbamoyl-1H-indazol-6-yl ester

HRID 2121858노트

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HRID 2121858 반응식
[CH2:1]([C:4]1[C:5]([O:13][C:14](=[O:16])[CH3:15])=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11][N:10]=[CH:9]2)[CH:2]=[CH2:3].[CH2:17]([N:19]=[C:20]=[O:21])[CH3:18]>C1COCC1>[CH2:1]([C:4]1[C:5]([O:13][C:14](=[O:16])[CH3:15])=[CH:6][CH:7]=[C:8]2[C:12]=1[N:11]([C:20](=[O:21])[NH:19][CH2:17][CH3:18])[N:10]=[CH:9]2)[CH:2]=[CH2:3]

참가 물질

4

반응물 2

HCID 8022Ethyl isocyanateHCID 69566045Acetic acid 7-allyl-1H-indazol-6-yl ester

생성물 1

HCID 69564705Acetic Acid 7-allyl-1-ethylcarbamoyl-1H-indazol-6-yl ester수율 81%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
70 °C

실험 절차

To a solution of the product from Step C (2.5 g, 11.6 mmol) in THF (10 mL) was added ethylisocyanate (1.01 ml, 13 mmol) and the mixture heated at 70° C. for 18 h. The reaction mixture was evaporated to a residue which was purified by chromatography (silica, 10% to 50% EtOAc/hexane) to give a colorless oil (2.70 g, 81%): LC/MS (+APCI) m/z 288 (M+H).

후처리

  1. customThe reaction mixture was evaporated to a residue which
  2. customwas purified by chromatography (silica, 10% to 50% EtOAc/hexane)

출처 및 근거

ORD 기록
ord-a6b520a00b7f41e2b238c721038bf00b
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06696476B2

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