Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → N-(4-Chloro-3-nitrophenyl)acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 4-Chloro-3-nitroaniline | HCID 12477 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(4-Chloro-3-nitrophenyl)acetamide | HCID 79672 | 96.5% |
반응 단계
To a stirred solution of 4-chloro-3-nitroaniline (17.3 g, 100 mmol) in DCM (150 mL) was added dropwise acetic anhydride (14 mL, 150 mmol) at ambient temperature. The mixture was stirred at ambient temperature for 2.5 h. The solvent was removed in vacuo, and Et2O was added to the residue. The precipitate was collected by filtration, washed with Et2O, and dried in vacuo to give N-(4-chloro-3-nitrophenyl)acetamide (20.7 g, 96%), which was used without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06696473B2 |
| 출처 데이터셋 | uspto-grants-2004_02 |
| ORD ID | ord-92b72ee7c9184a7282a64c27b1157a3c |
| 출처 메모 | uspto-grants-2004_02 |