m-Nitroacetophenone → 2-Chloro-1-(3-nitrophenyl)ethanone

HRID 2122056

반응식

HRID 2122056 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].S(Cl)([Cl:16])(=O)=O>C(OC(C)C)(C)C>[Cl:16][CH2:11][C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:12]

참가 물질

4

반응물 2

HCID 8494m-NitroacetophenoneHCID 24648Sulfuryl chloride

생성물 1

HCID 74372-Chloro-1-(3-nitrophenyl)ethanone수율 83.2%

시약·촉매·용매 1

HCID 7914Diisopropyl Ether용매

실험 절차

3′-Nitroacetophenone (2.00 g) was dissolved in diisopropyl ether (12.1 ml) and sulfuryl chloride (6.70 g) was added all at once thereto at 22° C. and refluxed for 6.5 hours. The reaction mixture was allowed to cool to room temperature while stirring, and the precipitated solids were filtered and washed with diisopropyl ether. Drying under reduced pressure yielded the desired 2-chloro-3′-nitroacetophenone (2.01 g; 83.1%).

후처리

  1. temperaturerefluxed for 6.5 hours
  2. filtrationthe precipitated solids were filtered
  3. washwashed with diisopropyl ether
  4. customDrying under reduced pressure

출처 및 근거

ORD 기록
ord-51086aa603e145a4ab2999cf686bed9a
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06696573B1

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