2-(Bromomethyl)-1,4-difluorobenzene → N-benzyl-2-(3-(2,5-difluorobenzyl)-2-oxopiperidin-1-yl)-4-methylthiazole-5-carboxamide

반응식

[Br:24][CH2:25][c:26]1[c:27]([F:33])[cH:28][cH:29][c:30]([F:32])[cH:31]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:10])[c:11]1[c:12]([CH3:23])[n:13][c:14]([N:16]2[C:17](=[O:22])[CH2:18][CH2:19][CH2:20][CH2:21]2)[s:15]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:10])[c:11]1[c:12]([CH3:23])[n:13][c:14]([N:16]2[C:17](=[O:22])[CH:18]([CH2:25][c:26]3[c:27]([F:33])[cH:28][cH:29][c:30]([F:32])[cH:31]3)[CH2:19][CH2:20][CH2:21]2)[s:15]1

참가 물질

반응물 2

HCID 5228302-(Bromomethyl)-1,4-difluorobenzene

HCID 24799232N-benzyl-4-methyl-2-(2-oxopiperidin-1-yl)thiazole-5-carboxamide

생성물 1

HCID 24801157N-benzyl-2-(3-(2,5-difluorobenzyl)-2-oxopiperidin-1-yl)-4-methylthiazole-5-carboxamide

출처 및 근거

ORD 기록: ord-76899ba25d7e4c55916d6cbc1821583c
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

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