Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloride methanol → 4-Chloro-5-hydroxy-7-iodoisoindolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloride methanol | HCID 21893726 | — |
| 반응물 | 4-Chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone | HCID 68493984 | — |
| 생성물 | 4-Chloro-5-hydroxy-7-iodoisoindolinone | HCID 68489249 | 58% |
반응 단계
In a similar manner to Step 6 of Example 139, 4-chloro-5-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (97.1 mg, 0.206 mmol) was treated with 10% hydrogen chloride-methanol solution (3 mL), followed by purification by slurry using diisopropylether to obtain 4-chloro-5-hydroxy-7-iodoisoindolinone (36.9 mg, yield 58%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745641B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-9e6bd2567c9c46e48a78b830e9111924 |
| 출처 메모 | uspto-grants-2010_06 |